Kathy Herbst

The purpose of this project is to establish a registry which warehouses data points for patients detected prenatally with hydronephrosis.  Data will be used to answer developing hypothesis, with the goals of:
–    increasing the working knowledge of outcomes and need for surgical intervention,
–    develop evidence-based guidelines to facilitate critical pathways for this population, and
–    assess the utilization of medical services such as clinical visits and the need for              radiologic imaging for this condition.

The Consortium on Urolithiasis in Pediatrics’ (CUP) mission statement is “Advancing research, prevention, and treatment of urolithiasis in children through a collaboration of pediatric nephrologists and urologists.” To advance this mission, CUP has developed the CUP Registry in order to produce reliable, longitudinal, patient care data about children who seek treatment for urolithiasis.

The aim of the CUP Registry (Registry) is to provide consortium members with a high-quality, multi-center, multi-disciplinary data source with in order to test developed hypothesis about pediatric urolithiasis.

Our study aim is to describe the rate and timing of renal related and survival outcomes for children diagnosed with PUV in United States children’s hospitals using the Pediatric Health Information System (PHIS) database. Our retrospective cohort study included children hospitalized 1/1/1992-12/31/2006, who were in their first year of life, had a diagnosis of congenital urethral stenosis, and underwent endoscopic valve ablation or urinary drainage intervention, or died. Records were searched through 12/31/2016 for renal related mortality, placement of a dialysis catheter, and renal transplantation. Cox regression analysis was used to identify risk factors, and Kaplan Meier survival analysis used to determine time-to-event probability. Subgroup survival analysis was performed with outcomes stratified by the strongest identified risk factor.